study of immunoglobulins igg, igm, iga and ige levels in serum and enumeration of b(cd22+) cells in iranian patients with behcet's disease

the behcet disease (bd) is a systemic inflammatory disease of unknown etiology. evidences suggest that at least some of the clinical aspect of the bd may be due to autoimmune responses, these includes elevated levels of immunoglobulins (igs) and immune complexes. to clarify the molecular basis of the changes in the level of different classes of igs in bd, we have detected the amount of igg, igm, iga, ige and number of b-cells (cd22+) in 68 patients with bd, 28 patients controls (pc) and 30 normal controls (nc). the amount of iga (p=0.0007), igm (p<0.000001) and ige (p=0.005) shows a significant chages in bd to comparied with the nc. but igg levels don&apos;t show any difference. the number of b-cells (cd22+) have not show any changes in bd in comparied to nc and pc. it seems that the elevation of different igs levels in the serum of patients may be due to unknown polyclonal stimulations then the elevation of igs caused the cic formation and complement activation which followed by tissue damages in bd patients.